Lichen sclerosus vulvae (LLS) is a dermatological condition that has intrigued scientists and physicians, and one of the aspects that has aroused interest is its possible connection to genetics. Surely, if your mother has been diagnosed with Lichen Sclerosus Vulvae and you begin to have discomfort, you may wonder, can I inherit Lichen Sclerosus Vulvae?


In this blog, we will dive into the relationship between Lichen Sclerosus and genetics, exploring studies, findings and what is known so far.

The Nature of Vulvar Lichen Sclerosus

SIL is a chronic skin disease affecting the external genital area of women. Symptoms include intense itching, redness, thinning of the skin and discomfort during sexual intercourse. Although it has been established that the exact trigger of LEV is unknown, the cause is currently thought to be multifactorial.

We will review some of the factors that may contribute to its occurrence:

Genetic Studies and Findings

Although no specific genetic marker for LEV has been identified, some studies suggest a genetic predisposition. Research has shown that 12% of women with LEV had a first-degree relative affected.

These findings support the idea that genetic factors may contribute to LEV susceptibility.

From the
Nixarian Foundation
we continue researching Lichen Sclerosus and discovering advances to give a better quality of life to women suffering from this disease.

The Influence of genes on the immune response

LEV has been observed to have autoimmune features, suggesting that the immune system may play a role in its development. Genetics may be linked to how the immune system responds to triggers, which could explain why some people develop LEV while others do not, even when exposed to similar conditions.

In addition, up to one third of women with lichen also suffer from some autoimmune disease: Hashimoto’s thyroiditis, vitiligo, pernicious anemia, alopecia areata, among others.

Environmental and Genetic Factors: A Complex Relationship

It is important to note that genetics is not the only determining factor in the development of LEV. The interaction between genetic and environmental factors may play a crucial role.

Exposure to irritants, hormonal imbalances and other external influences may also contribute to the manifestation of LEV.

Implications of genetics for prevention and treatment.

The relationship between lichen sclerosus vulvae and genetics is an evolving field. While genetic predisposition may increase risk, interaction with environmental factors and immune response also play a significant role.

As research progresses, it is hoped that a more complete understanding of LEV genetics will be achieved. The future diagnosis of this condition involves the identification of genes or proteins that serve as biomarkers for LEV, thus accelerating the diagnostic process to prevent complications.

If you want to know more about Vulvar Lichen Sclerosus and its current treatments, don’t miss this article.